Clinical Neuropsychology and Brain Function: Research, by Thomas Boll, Brenda K. Bryant

By Thomas Boll, Brenda K. Bryant

This paintings includes chapters at the development of neuropsychological study written by way of recognized psychologists. They document on a extensive diversity of subject matters, addressing uncomplicated and utilized matters within the box. Empirical and theoretical advances in our wisdom of mind functionality are explored.

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Rosen, & N. ), Plasticity and recovery of function in the central nervous system (pp. 429-466). New York: Academic Press. Dalyrimple-Alford,J. , & Kelche, C. (1985). Behavioral effects of pre-operativepost-operative differential housing in rats with brain lesions: A review. In B. E. Will, P. Schmitt, & J. D. ), Brain plasticity, learning, and memory. Advances in Behavioral Biology, 28, 441-458. Dunnett, S. , Low, W. , Iversen, S. , & Bjorklund, A. (1982). Septa1 transplants restore maze learning in rats with fornix-fimbria lesions.

Trials to criterion on a spatial alternation task in adult rats with frontal cortex lesions given embryonic brain tissue transplants 7, 14, 30, or 60 days after receiving bilateral frontal cortex injuries. Adapted from Stein, Palatucci, Kahn, and Labbe (1988) by permission. After all behavioral testing was completed, the rats were killed and their brains taken for histological examination. Based on our finding that the rats with postinjury transplants at 30 or 60 days had hardly any viable transplant tissue in the zone of injury, it was not surprising that these two groups evidenced no behavioral recovery on the learning task.

We reasoned that the most direct examination of whether the transplants are necessary to maintain functional recovery, would be to remove them after observing an initial effect and then retest the subjects on a new task. This experiment essentially consisted of four groups of adult, male animals. Three of the groups (10 rats per group) received bilateral removals of the medial frontal cortex and one served as a sham-operated control. Two of the groups with lesions received transplants of E-19 frontal cortex directly into the zone of injury 7 days after the lesions were created.

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