Clinical Nephrotoxins: Renal Injury from Drugs and Chemicals by William M. Bennett, Gilbert Deray, Marc E. de Broe, George

By William M. Bennett, Gilbert Deray, Marc E. de Broe, George A. Porter

Scientific Nephrotoxins: Renal harm from medicines and chemical compounds, 3rd version is a finished textual content on all points of inauspicious results via medicines, chemicals and radiation at the kidneys. the significance of the toxicity of substances and different ingredients for the kidneys is more and more well-known. The e-book contains subject matters comparable to scientific relevance, renal dealing with and mobile mechanisms of nephrotoxicity, in addition to animal and phone tradition types. additionally, the quantity highlights particular forms of medicinal drugs, comparable to anti-infectious brokers and anti inflammatory, cardiovascular and anti-cancer medicines. The final part bargains with prevention and makes a speciality of urinary biomarkers, pharmacological features and drug dosage in renal failure. during this 3rd and entirely revised version, a number of new issues have been extra and extra figures and tables may be integrated. The e-book is of curiosity for the nephrologist, internist, medical professional, toxicologist, pharmacologist, anesthesiologist, epidemiologist, public well-being reliable, pharmaceutical undefined, and nationwide drug protection committees, between others.

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The use of these drugs under normal circumstances when renal perfusion is adequate poses very little problem. However when these drugs are used in states of prerenal azotemia, renal artery stenosis or concomitantly with other drugs such as NSAIDs, renal failure may ensue. In general AKI under these circumstances is reversible following their discontinuation. Other drugs that cause altered glomerular hemodynamics Drugs such as cyclosporine and tacrolimus, belong to a class of commonly used immunsuppressants for organ transplantation referred to as calcineurin inhibitors.

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168. Rodriguez-Puyol D. The aging kidney. Kidney Int 1998; 54: 2247-2265 169. Bennett WM. Geriatric pharmacokinetics and the kidney. Am J Kidney Dis 1990; 16: 283-288. 170. Fried L, Solomon C, Shlipak M, Seliger S, Stehman-Breen C, Bleyer AJ, Chaves P, Furberg C, Kuller L, Newman A. Inflammatory and prothrombic markers and the progression of renal disease in elderly individuals. J Am Soc Nephrol. 2004;15:3184-3191 171. Kohli HS, Bhaskaran MC, Muthukumar T, Thennarasu K, Sud K, Jha V, Gupta KL, Sakhuja V.

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