Brenner and Rector's the Kidney: Expert Consult - Online and by Maarten W. Taal MBChB MMed MD FCP(SA) FRCP, Glenn M.

By Maarten W. Taal MBChB MMed MD FCP(SA) FRCP, Glenn M. Chertow MD, Philip A. Marsden MD, Karl Skorecki MD FRCP(C) FASN, Alan S. L. Yu MD, Barry M. Brenner MD AM(Hon) DSc(Hon) DMSc(Hon) FRCP(Lond Hon)

Conquer the hardest medical demanding situations in nephrology with the recent ninth variation of Brenner/Rector's The Kidney! A brand-new editorial staff of Drs. Maarten W. Taal, Glenn M. Chertow, Philip A. Marsden, Karl Skorecki, Alan S. L. Yu, and Barry M. Brenner,, including a various record of foreign participants carry you the newest wisdom and most sensible practices on each entrance in nephrology all over the world. Brand-new sections on worldwide concerns in Nephrology and Pediatric Nephrology, in addition to new chapters on fresh medical trials, cardiovascular and renal threat prediction in persistent kidney affliction, id of genetic motives of kidney disorder, and so on, preserve you on the leading edge of this speedily transforming into, ever-changing distinctiveness. In print and on-line at www.expertconsult.com, with commonplace updates reflecting new advancements, Brenner/Rector continues to be the go-to source for working towards and coaching nephrologists and internists who desire to grasp uncomplicated technological know-how, pathophysiology, and medical most sensible practices. expand your wisdom base with specialist, liable, entire solutions for each degree of your profession from the main accomplished, definitive scientific reference within the box! organize for certification or recertification with a assessment of the elemental technological know-how that underpins scientific nephrology in addition to a complete collection of an important bibliographical assets in nephrology. Visually take hold of and higher comprehend severe info because of over seven hundred full-color top quality pictures in addition to conscientiously selected figures, algorithms, and tables to demonstrate crucial options, nuances of medical presentation and method, and choice making. Get the world over varied, relied on suggestions and views from a workforce of well-respected international participants, all of whom are on the most sensible and the innovative of your box. a brand new editorial crew headed through Dr. Taal and hand-picked through Dr. Brenner guarantees the continued adherence to past criteria of excellence. entry info speedy because of a brand new, reorganized print layout and simply searchable on-line entry to supplemental figures, tables, extra references, and improved discussions in addition to average on-line updates, case reports, and extra at www.expertconsult.com. preserve present with the quick improvement of care and study around the world. a brand new part, "Global Considerations", specializes in areas outdoors Europe and North the USA. prime specialists from Latin the USA, Africa, close to and heart East, Indian Subcontinent, a ways East, Oceania and Australia current their professional insights into particular stipulations, in addition to development and demanding situations within the improvement of the area of expertise. increase remedy and results for kids with renal sickness. New to this version, "Pediatric Nephrology" addresses renal pathologies that sometimes found in adolescence and covers issues akin to Maturation of Kidney constitution and serve as; Fluid; Electrolyte and Acid-Base problems in little ones; ailments of the Kidney and Urinary Tract in young children; Dialysis in childrens; and Kidney Transplantation in young children. not sleep thus far with all of the most recent medical info together with contemporary scientific trials, genetic factors of kidney sickness, and cardiovascular and renal danger prediction in persistent kidney sickness. The must-have source for studying all parts of nephrology, generally revised and with new international specialists. Your buy entitles you to entry the website till the following variation is released, or until eventually the present variation isn't any longer provided on the market by means of Elsevier, whichever happens first. If the following variation is released lower than twelve months after your buy, you may be entitled to on-line entry for three hundred and sixty five days out of your date of buy. Elsevier reserves the best to supply an appropriate substitute product (such as a downloadable or CD-ROM-based digital model) should still entry to the website be discontinued.

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Extra info for Brenner and Rector's the Kidney: Expert Consult - Online and Print 2-Volume Set

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Mutant cells epithelialize and form nephrons normally as long as they are surrounded by wild-type stromal cells, in keeping with the model outlined in Figures 1-5 and 1-9). In addition, there is a cell-autonomous requirement for Pod1 in stromal mesenchymal cells to allow differentiation into interstitial cell and pericyte cell lineages of the cortex and medulla as Pod1 null ES cells were unable to contribute to these populations. Although many of the defects in the Pod1 mutant kidneys phenocopy those seen in the Bf2 mutant kidneys, there are important differences.

Genomewide-based approaches have two major advantages over reverse genetics: (1) Most KOs lead to major gene disruptions, which may not be relevant to the subtle gene alterations that underlie human renal disease, and (2) many of the complex traits underlying congenital anomalies and acquired diseases of the kidney are unknown, which makes predictions about the nature of the genes that are involved in these diseases difficult. One of the most powerful and well-characterized mutagens in the mouse is the chemical mutagen N-ethyl-N-­nitrosourea (ENU).

156 Since 2000, a number of growth factors and their receptors that are required for vasculogenesis and angiogenesis have been identified. c. 157 These data demonstrate gene dosage sensitivity to VEGF-A during development. In the developing kidney, podocytes and renal tubular epithelial cells express VEGF-A158 and continue to express it constitutively in the adult kidney, while the cognate tyrosine kinase receptors for VEGF-A, VEGFR-1 (Flt1), and VEGFR-2 (Flk1/KDR) are predominantly expressed by all endothelial cells.

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