B Cell Receptor Signaling by Tomohiro Kurosaki, Jürgen Wienands

By Tomohiro Kurosaki, Jürgen Wienands

This quantity info our present realizing of the structure and signaling functions of the B mobilephone antigen receptor (BCR) in health and wellbeing and sickness. the 1st chapters assessment new insights into the meeting of BCR parts and their association at the mobile floor. next contributions specialise in the molecular interactions that attach the BCR with significant intracellular signaling pathways equivalent to Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. those parts orchestrate cytoplasmic and nuclear responses in addition to cytoskeleton dynamics for antigen internalization. in addition, a key mechanism of ways B cells take into account their cognate antigen is mentioned intimately. Altogether, the discoveries provided supply a greater realizing of B mobile biology and support to provide an explanation for a few B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B mobilephone tumors, whereas additionally paving the way in which for finally fighting those diseases.

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