Atlas of CSF cytology by Harald Kluge

By Harald Kluge

A entire, single-volume reference for the cytological exam of
cerebrospinal fluid!

This full-color atlas offers the entire crucial
information wanted for achieving a correct cytological analysis of
cerebrospinal fluid and its abnormalities. Designed as a medical and laboratory
reference, Atlas of CSF Cytology presents an summary of the entire commonplace
diagnostic innovations and provides perception into complicated equipment equivalent to circulation
cytometry and immunocytological phenotyping. short descriptions of the
indications, benefits, and boundaries are supplied for every technique. An
extensive number of greater than three hundred top quality cytological photographs
demonstrating general mobile constructions, in addition to pathological cells in acute and
remission stages permits the reader to appreciate ailment processes.

Highlights:

  • Guidelines for the correct dealing with of specimens, mobile instruction, and marking
    techniques
  • Review of the typical resources of errors in analysis
  • Thorough insurance of the innovations for detecting and classifying inflammatory,
    infectious, neoplastic, and hemorrhagic stipulations of the critical fearful procedure
  • Descriptions of the main positive aspects of cells and the type of tumor
    cell kinds in response to present W.H.O. criteria
  • Full-color photos depicting pathological changes of CSF cells -- an essential visible reduction to
    comprehension

Atlas of CSF Cytology is perfect for experts in neurology,
neurosurgery, pathology/neuropathology, cytopathology, microbiology, and
laboratory drugs, in addition to for these internists, pediatricians, and
psychiatrists who usually request cytological exam of the CSF. notwithstanding
it is written to fulfill the desires of experts, the "Atlas" can also be discovered
accessible and enlightening through clinical scholars, interns and
residents.

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Extra resources for Atlas of CSF cytology

Sample text

The distinction is of obvious importance in differential diagnosis. Iron-free hematoidin (identical to bilirubin) is formed in the final stage of hemoglobin breakdown. It is seen as amorphous, brownish-yellow or yellowish crystalline deposits, which can be either intracellular or extracellular after phage autolysis (Figs. 31). Macrophages or hematomacrophages that have phagocytosed not only erythrocytes and/or hemosiderin, but also white blood cells, are called multipotent macrophages (Figs. 26).

2006 Chapter-3 Cytological Findings in Infectious and Inflammatory Diseases Fig. 17 Mononuclear phase (secondary phase) during remission of Escherichia coli meningitis (the polynuclear initial phase had entered remission 6 days after onset). a Lymphocytic-monocytic cell picture with cells in various stages of differentiation after the end of the initial polynuclear (granulocytic) phase. b Cell picture 1 week later: monocytes in various states of activation, some in an endotheliumlike arrangement and others separate, with strongly dispersed cytoplasm and an irregularly contoured cell membrane (“signet ring storage form”).

It contains fine acidophilic granules, and it usually has an irregular border with protuberances and pseudopodia. The activated monocytes or histiocytes are occasionally already engaged in erythro- and/or lipophagocytosis at this early stage (Figs. 9). This is most commonly seen in children in the early phase of hemorrhage into the CSF space. Erythrophages are the first type of hematomacrophage to develop from the activated cells of monocytic origin (see Figs. 11). They appear in the CSF about 8–12 hours after the precipitating hemorrhage (in the literature times range from 8 to 24 hours), rapidly increase in number in accordance with the extent and severity of the hemorrhage, and begin the task of the enzymatic breakdown of hemoglobin.

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