Amyotrophic Lateral Sclerosis: A Synthesis of Research and by Andrew Eisen, Charles Krieger

By Andrew Eisen, Charles Krieger

Amyotrophic Lateral Sclerosis, differently often called Lou Gehrig's ailment, is among the degenerative ailments of the getting older frightened method. this article smartly synthesizes the new explosion of study into this actual situation to build a close and complete evaluation. Drs. Eisen and Krieger convey their examine services and wide scientific event to supply this sensible and thought-provoking account. Chapters hide the epidemiology, molecular biology, and pathophysiology of ALS, in addition to concerns pertinent to medical overview and care.

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There is not a good explanation for the greater number of younger men developing ALS. However, the motoneuron is an androgen target tissue and the density of androgen receptors may be greater on those neurons that are preferentially affected in ALS. The possible role of DHEA in the development of ALS in younger men has already been discussed above. Women developing ALS often have a later menarche and an earlier menopause than usual, making a shorter reproductive period, which could suggest that oestrogens may be relatively protective.

This has not substantially changed since the earliest descriptions of the disorder, although there has been a rising incidence of the disease and maybe more younger people with it are being recognized (see below). However, over the one and a half centuries since ALS was first recognized and described, longevity has steadily risen from a mean survival of about 45 years in 1850 to a mean approaching 80 years in 1996. Epidemiological studies in the early 1950s indicated that more than 75 per cent of deaths from ALS were in patients who were older than 54 years of age (Kurland, Choi and Sayre, 1969).

1991). 1 years. 5 years respectively). 7 shows the second-order exponential relationship, for men and women, which best fitted the data relating onset age and disease duration. It also shows the 75th and 95th upper prediction bounds on disease duration at each age, and the corresponding life expectancy for the population of British Columbia for the years 1993-1995. 7. Kaplan-Meier survival curves by sex (top) and age (bottom). The survival curves are not significantly different for men and women.

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