Aminocyclitol Antibiotics by Kenneth L. Rinehart, Jr. and Tetsuo Suami (Eds.)

By Kenneth L. Rinehart, Jr. and Tetsuo Suami (Eds.)

content material: Aminocyclitol antibiotics : an creation / Kenneth L. Rinehart, Jr. and Lois S. protect --
Synthesis of aminocyclitol antibiotics / S. Umezawa --
amendment of aminocyclitol antibiotics / Tetsuo Suami --
Syntheses of some branched-chain aminocyclitol antibiotics / Juji Yoshimura, Masuo Funabashi, and Chung-Gi Shin --
a brand new synthesis of branched-chain epi-configuration deoxyhalogeno- and deoxyaminocyclitols / Donald E. Kiely and James M. Riordan --
The stereospecific synthesis of spectinomycin / D.R. White, R.D. Birkenmeyer, R.C. Thomas, S.A. Mizsak, and V.H. Wiley --
Synthesis of spectinomycin analogs / R.C. Thomas, D.R. White, V.H. Wiley, and D.A. Forster --
Spectinomycin amendment / W. Rosenbrook, Jr. and Ronald E. Carney --
The buildings of diastereomers of dihydrospectinomycins / Louise Foley and Manfred Weigele --
Chemical amendment of aminoglycosides : a singular synthesis of 6-deoxyaminoglycosides / Barney J. Magerlein --
The impression of O-methylation at the job of aminoglycosides / J.B. McAlpine, R.E. Carney, R.L. Devault, A.C. Sinclair, R.S. Egan, M. Cirovic, R. Stanaszek, and S. Mueller --
The synthesis and organic houses of 3'- and 4'-thiodeoxyneamines and 4'-thiodeoxykanamycin B / Thomas W. Ku, Robert D. Sitrin, David J. Cooper, John R.E. Hoover, and Jerry A. Weisbach --
Synthesis of analogs of kanamycin B / J.P.H. Verheyden, D.B. Repke, T.C. Tompkins, and J.G. Moffatt --
The selective N-acylation of kanamycin A / M.J. Cron, J.G. Keil, J.S. Lin, M.V. Ruggeri, and D. Walker --
Carbon-13 NMR spectra of aminoglycoside antibiotics / Takayuki Naito, Soichiro Toda, Susumu Nakagawa, and Hiroshi Kawaguchi --
The constructions of juvenile elements of the fortimicin complicated / J.B. McAlpine, R.S. Egan, R.S. Stanaszek, M. Cirovic, S.L. Mueller, R.E. Carney, P. Collum, E.E. Fager, A.W. Goldstein, D.J. Grampovnik, P. Kurath, J.R. Martin, G.G. publish, J.H. Seely, and J. Tadanier --
The buildings of latest fortimicins having double bonds of their purpurosamine moieties / Kunikatsu Shirahata, Gen Shimura, Seigo Takasawa, Takao Iida, and Keiichi Takahashi --
Enzymes editing aminocyclitol antibiotics and their roles in resistance selection and biosynthesis / Julian Davies --
Biosynthesis and mutasynthesis of aminocyclitol antibiotics / Kenneth L. Rinehart, Jr. --
Chemical and organic amendment of antibiotics of the gentamicin team --
P.J.L. Daniels, D.F. Rane, S.W. McCombie, R.T. Testa, J.J. Wright, and T.L. Nagabhushan --
Synthesis and mutasynthesis of pseudosaccharides on the topic of aminocyclitol-glycoside antibiotics / J. Cléophax, A. Roland, C. Colas, L. Castellanos, S.D. Géro, A.M. Sepulchre, and B. Quiclet --
a number of interactions of aminoglycoside antibiotics with ribosomes / Bernard D. Davis and Phang-C. Tai.

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Takagi, Y . , Miyake, T . , Tsuchiya, T . , Umezawa, S. , J. Antibiot. (Tokyo), (1973), 26, 403. Evans, M. E . , Parrish, F. W. and Long, L. , Carbohyd. , (1967), 3, 453. Takagi, Y . , Tsuchiya, T . , Sano, H. , Bull. Chem. Soc. , (1976), 49, 3108. , Tsuchiya, T . , Umezawa, S. , J. Antibiot. (Tokyo), (1972), 25, 741. , Takagi, Y. and Tsuchiya, T . , Bull. Chem. Soc. , (1971), 44, 1411. , Pure & Appl. 11/12, 1453 1476. Kumar, V. and Remers, W. , J. Org. , (1978), 43, 3327. Rinehart, K. L. Jr. , J.

I n t h i s d e r i v a t i v e , the 3'- and 4 - h y d r o x y l groups a r e deoxygenated, the 1-amino group i s a c y l a t e d w i t h HABA, and furthermore 6'-amino group i s methylated i n order t o prevent 6'N - a c e t y l a t i o n by a c e t y l t r a n s f e r a s e enzymes. ch002 f fl f f f f f fl ? ch002 00 Nal-Zn^ DMF NHTs \ Nal/DMF TsHN ,0 NHTs "QV VQ 3 2 Dibekacin ( MM ) Figure 13. (VV) (WW) Amikacin Butirosin Β Figure 14. 2. UMEZAWA 33 Synthesis of Aminocyclitol Antibiotics i n h i b i t s almost a l l i n a c t i v a t i o n s by phosphotransferases, a d e n y l y I t r a n s f e r a s e s , and a c e t y l t r a n s f e r a s e s .

Tokyo), (1968), 21, 367. , Tatsuta, K. , Bull. Chem. Soc. , (1969), 42, 533. , Nishimura, Y. and Tsumura, T . , J. Antibiot. (Tokyo), (1968), 21, 424. , Nishimura, Y. and Tsumura, T . , Bull. Chem. Soc. , (1969), 42, 537. , Tatsuta, K. and Tsumura, T . , J. Antibiot. (Tokyo), (1968), 21, 162. , Tatsuta, K. and Tsumura, T . , Bull. Chem. Soc. , (1969), 42, 529. , Tsuchiya, T . , Umezawa, S. , J. Antibiot. (Tokyo), (1972), 25, 741. Takagi, Y . , Miyake, T . , Tsuchiya, T . , Umezawa, S. , J. Antibiot.

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